How does the transition between the proto-semiosic material relation, established between two molecules, and a historical-natural language happen, and what changes does it bring? How much in common do cellular semiosis and human semiosis have? It is necessary to understand how Prodi explains the evolution of semiosis, from its most simple forms to the more complex ones. The problem is how to maintain the continuity of the biological process without underplaying the radical discontinuities it constantly engenders.