Neurophilosophical pragmatism, or neuropragmatism, is a scientifically informed treatment of cognition, knowledge, the body-mind relation, agency, socialization, and further issues predicated on sound judgments about these basic matters. Neuropragmatism is capable of grappling with philosophical questions arising at many levels, from synapse to society. There is much at stake, as the epigraph by Dewey states. With its firm grounding in science, neuropragmatism may be the philosophy best equipped to deal productively with the challenges facing our culture, as developments in neuroscience and neurotechnology bring about both better means for dealing with old problems, and new ways of creating and dealing with the problems of today and tomorrow.