Prostate cancer (PCa) is a disease in which understandings of what it means to be a man and structural inequalities affecting men from different groups intersect and interact in important and complex ways at every stage of the disease "journey" from first noticing a problem, to seeking help and obtaining a diagnosis through treatment to survivorship. PCa needs to be understood with reference to prevailing norms and enactments of masculinity and to the ethnicity and social class of the man with cancer. This chapter will provide basic information about the nature, symptoms and treatment of prostate cancer. It will discuss these in terms of their psychological and psychosocial impact on men and their families, with a particular focus on how concepts of masculinity as well as ethnicity, sexual orientation and gender identity shape these effects.