In his Metaphysical Foundations of Natural Science, Kant presents the "pure part" of natural science – that is, the a priori principles holding of matter. This special metaphysics of matter is, Kant claims, grounded on the general metaphysics of nature described in the System of Principles of his first Critique. This chapter develops a comprehensive account of Kant's framework for natural science that touches on interpretive issues that arise in the transition from general to special metaphysics and that outlines his dynamics and its limitations.